[Analysis of melatonin concentration and its correlation with ovarian disfunction among obese women of reproductive age].

One of the new directions in the study of reproductive disorders in obese women is the effect and receptor sensitivity of  melatonin on the gonadotropic function of the pituitary gland and ovariogenesis, taking into account the chronology of «light pollution¼. At the present stage, there is very little literature on the influence of the aspects of «light pollution¼ on the problem of obesity and reproductive disorders in the literature. This review is an attempt to combine the above problem in terms of the impact of «light pollution¼ and the level of receptor sensitivity of melatonin in women of reproductive age with obesity. The literature search was carried out in Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. Free access to the full text of the articles was a priority. The selection of sources was prioritized for the period from 2015 to 2019. However, given the insufficient knowledge of the chosen topic, the choice of sources was dated from 1992. The work was carried out as part of the study «Central and peripheral pathophysiological mechanisms of development of adipose tissue diseases, taking into account clinical and hormonal characteristics¼ 2020-2022.

Formation of metabolic syndrome as a risk factor of circulatory diseases in drivers.

The authors considered systemic approaches to disclosing factors that promote metabolic syndrome formation and associated risk of ciculatory system diseases in drivers. Examination covered drivers with metabolic syndrome and without it. Findings are that metabolic disorders developing in drivers are occupationally conditioned. Length of service can determine cases numbers of cardiovascular disorders, diabetes mellitus manifestations, more frequent combination of hyperglycemia and/or hyper-, dyslipidemia with abdominal obesity. The drivers with length of service over 15 years, aged over 35, demonstrated arterial hypertension in 35% of cases, postinfarction cardiosclerosis in 43% of cases, disorders of cardiac rhythm and conductivity in 55% of cases, and the number increases with length of service and reaches 80% of total examinees number by 55 years of age. Diabetes mellitus was diagnosed in 37% of cases (in 75% of the workers first diagnosed) with over 20 years of service, average age of 50 years.

On occupational fitness examination of workers exposed to occupational hazards after coronary artery bypass grafting.

Myocardium revascularization in coronary heart disease patients is one of the most important treatment modalities. Considerable improvement of somatic state after surgery for IHD is seen in 82-83% of patients in average, whereas only hardly more than a half return to occupational activity without decrease in preoperative level of qualification and performance. In occupational therapy and industrial medicine clinic with FBSI <>, examination covered 68 workers of Perm' area enterprises, derected for occupational fitness study after coronary artery bypass grafting and 100 workers at various terms after myocardium infarction, with verified IHD. Risk factors evaluation demonstrated that after coronary artery bypass grafting 75% of patients are motivated to maintain healthy lifestyle and compliance to treatment over 5 years; positive changes in a year according to functional study were seen in 75% of cases; level of blood pressure in office 127.8±9.4 mm Hg; dyslipidemia, hypercholesterolemia remain in 11.7% of cases. At first stage, criteria of permit-to-work are: decrease in functional class of chronic cardiac failure to 0-II degrees from initial one; absence of exertional stenocardia or exertional stenocardia less than II degree, absence of ventricular arrhythmias of high grade.

[Diagnostics of olfactory disorders in the patients with Parkinson's disease and polypous sinusitis with the use of the Sniffin' Sticks test].

The objective of the present study was the characteristic of the sense of smell and comparison of its peculiarities in the patients presenting with Parkinson's disease and polypous sinusitis based on the results of otorhinolaryngological examination with the use of the Sniffin' Sticks test. A total of 31 patients with polypous rhinosinusitis (PRS) (18 men and 17 women at the age of 44-58 years ) and 97 patients with Parkinson's disease (PD) (47 men and 50 women at the age of 50-56 years) were enrolled in the study. It was shown that 85% of the patients with PRS and PD suffered from olfactory disorders. The evaluation of selected parameters determined by the Sniffin' Sticks test demonstrated the impairment of the sense of smell in 48% of the patients with PRS and in 54% of those having PD. The main difference between the two groups was in the odour threshold that was reduced in 97% of the patients with PRS and in 72% of the cases with PD and in the ability to distinguish between odours that was compromised in 37% and 78% of these patients respectively.

[Problems of occupational fitness conclusion on periodic medical examination].

Additional examination in Occupational Pathology Center are economic loss both for employer and employee, as the employee receives payment for those days when in the examination. Analysis of over 600 cases of occupational fitness examination in Occupational Pathology Center according to referrals given by medical institutions providing periodic medical examination shows that in most cases the conclusion was possible during periodic medical examination. Difficulties in conclusion on workers' fitness for occupation during periodic medical examination, according to our viewpoint, result not from limited diagnostic facilities for adequate examination and unfitness disclosure, but from lack of information in primary medical documentation and inadequacy of occupational factor and work characteristics presented by employer to actual working conditions.

[Treatment of occupational neurosensory deafness and noises in internal ear].

Neurosensory deafness treatment can be effective only after removal of specific etiologic factor--exposure toindustrial noise, that necessitates change of work and occupation, i.e. occupational disablement. Search for effective, complex methods to treat and prevent neurosensory deafness in patients exposed to occupational noise remains topical problem in otorhinolaryngology and occupational therapy. The article presents a method of treatment and prevention of neurosensory deafness in patients exposed to occupational noise; demonstrates its efficiency. Combination of medical therapy and physical therapy improves function of conductive pathways of hearing analyser, enables adequate rehabilitation of hearing in workers--that was confirmed by audiologic and neurofunctional parameters. The method is inexpensive, can be operative in medical stations at enterprises.

[Respiratory diseases in metallurgy production workers].

The authors identified features of respiratory diseases in workers of various metallurgy workshops. Cause-effect relationships are defined between occupational risk factors and respiratory diseases, with determining the affection level.

[Features of hemostasis and thrombocyte function in the yellow suslik]. / Osobennosti gemostaza i funktsii trombotsitov u zheltogo suslika.

High levels of blood-coagulating factors and of antithrombin III low plasma tolerance of heparin, high velocity of Hageman-dependent processes of prothrombinase formation and plasminogen activation were found in yellow suslik. The level of hemostasis processes in hibernating animals is related to change of their functional state during an intense ontogenetic development and adequate to their physiological activity in seasonal cycle.

[Nucleotide sequences in DNA showing preferential binding with distamycin A and acridine derivatives]. / Nukleotidnye posledovatel'nosti v DNK, predpochtitel'nye dlia sviazyvaniia distamitsina A i proizvodnykh akridina.

The specificity of DNA X dye binding was studied. Antibiotic distamycin A was bound most strongly to the DNA sequences composed of three or more neighboring A X T pairs. Acrichin and 7-aminoacrichin proved to be weak specific inhibitors binding predominantly within the A X T regions.